Which agent functions as a gepant?

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Prepare for the Pharmacology IV – Headache Therapeutics Test. Review the therapeutic approaches, tackle multiple-choice questions with explanations, and boost your test-taking confidence. Ace your exam with precision!

Multiple Choice

Which agent functions as a gepant?

Explanation:
Gepants are small‑molecule antagonists of the CGRP receptor, designed to block CGRP signaling involved in migraine. Rimegepant is a gepant because it directly blocks the CGRP receptor, and is used for acute treatment of migraine. The other options are not gepants: erenumab is a monoclonal antibody targeting the CGRP receptor, and galcanezumab is a monoclonal antibody targeting the CGRP ligand—both are biologics with different pharmacokinetics and clinical uses. Amitriptyline is a tricyclic antidepressant used for migraine prophylaxis through monoaminergic mechanisms, not CGRP receptor antagonism. Therefore, the agent that functions as a gepant is rimegepant.

Gepants are small‑molecule antagonists of the CGRP receptor, designed to block CGRP signaling involved in migraine. Rimegepant is a gepant because it directly blocks the CGRP receptor, and is used for acute treatment of migraine. The other options are not gepants: erenumab is a monoclonal antibody targeting the CGRP receptor, and galcanezumab is a monoclonal antibody targeting the CGRP ligand—both are biologics with different pharmacokinetics and clinical uses. Amitriptyline is a tricyclic antidepressant used for migraine prophylaxis through monoaminergic mechanisms, not CGRP receptor antagonism. Therefore, the agent that functions as a gepant is rimegepant.

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