Pharmacology IV – Headache Therapeutics Practice Test

Dihydroergotamine has very limited and variable oral absorption, so it isn’t given by mouth. The effective routes for acute migraine treatment are intravenous or intranasal, with the nasal form providing rapid relief and IV administration used in clinical settings. To improve tolerability and, in the IV route, absorption, an antiemetic like metoclopramide may be given with fluids. Therefore, IV or nasal administration, sometimes with IV metoclopramide and fluids, is the correct approach. The other routes listed (oral, intramuscular, inhaled) are not standard for DHE in this context.