Pharmacology IV – Headache Therapeutics Practice Test

These questions are part of the practice quiz. Start practicing

• Which of the following is an oral CGRP antagonist approved for migraine prevention?
• What is a common adverse effect of amitriptyline relevant to older patients?
• What is a key hepatic safety consideration when using gepants?
• How do CGRP monoclonal antibodies become prescribed in terms of administration?
• Which CGRP pathway blocking agents are all administered by subcutaneous injection?
• Which non-oral therapy can be used for acute migraine in an emergency department setting?
• Which of the following describes the adverse effects of topiramate?
• In pediatric migraine therapy, how does dosing generally differ from adults?
• What strategy can reduce tachyphylaxis when using triptans?
• How is cluster headache diagnosed?
• Which of the following is a secondary cause to consider in the differential diagnosis of migraine?
• Which statement about neuromodulation devices is true?
• Which educational approach helps minimize tachyphylaxis in migraine management?
• What is used for cluster headache abortive therapy?
• What is required when considering pediatric dosing for migraines?
• Which statement about rizatriptan in pediatric use is accurate?
• Which therapy is commonly used for status migrainosus in a hospital setting?
• Which of the following lists the adverse drug reactions of candesartan?
• Which class is a nonspecific serotonin receptor agonist and vasoconstrictor?
• Which of the following is NOT part of the POUND mnemonic for migraines?
• Which pair of lifestyle factors is commonly recommended to avoid in migraine management?
• Which of the following is a precaution or adverse effect associated with divalproex?
• What is the mechanism of action of ergotamines?
• What are the adverse drug reactions of rimegepant (Nurtec)?
• Which statement best describes a common adverse effect of venlafaxine when used for migraine prevention?
• Which of the following is included in the differential diagnosis for migraine headache?
• What is the central role of CGRP in migraine pathophysiology?
• If analgesics and triptans are ineffective or contraindicated, which newer abortive therapies may be used?
• Which monoclonal antibody is used for migraine prophylaxis?
• Which propranolol-related concern limits its use in patients with asthma or COPD?
• Which statement about CGRP monoclonal antibodies is most accurate?
• Which of the following drug classes was not described as a migraine preventive option in the material?
• Which statement best describes the pattern of episodic cluster headaches?
• In patients without pre-existing CAD, the risk of myocardial infarction with triptans is:
• How can non-pharmacologic therapies improve migraine outcomes?
• What fundoscopic findings could be abnormal in migraine patients?
• In elderly patients, which preventive migraine medication is generally favored due to a safer cognitive profile?
• Which combination is most commonly used for over-the-counter migraine relief?
• Which statement accurately reflects acute migraine treatment options?
• According to ICHD-3 criteria, what constitutes migraine without aura?
• Which option describes CGRP antagonists used for migraine prevention in monoclonal antibody form?
• Which neuromodulation device is approved for cluster headache?
• Common ADRs of erenumab include which of the following?
• Which statement best describes the diagnostic criteria for migraine without aura?
• Which acute migraine therapy is associated with driving impairment and notable CNS effects?
• Which statement about adverse effects of CGRP antagonists is NOT true?
• How do triptans relieve acute migraine symptoms?
• In patients with pre-existing coronary artery disease, triptans may cause which adverse event?
• Which of the following describes a common adverse effect of onabotulinumtoxin A for migraine prophylaxis?
• Which of the following represents other migraine treatment options mentioned beyond standard analgesics?
• Which is a recommended treatment for mild-moderate tension-type headache?
• Antiemetics such as metoclopramide or prochlorperazine are used with acute migraine therapy primarily to:
• What is a goal of long-term migraine management?
• Why is pediatric safety data important in migraine medications?
• Typical botox regimen for chronic migraine?
• Acetaminophen plays what role in acute migraine management?
• During a migraine attack, CGRP release contributes to which two processes?
• Which CGRP ligand-targeting monoclonal antibody is used for migraine prevention?
• What is the typical timeframe to evaluate the effectiveness of a preventive therapy?
• Concomitant use of ergot derivatives with triptans is contraindicated because of the risk of what?
• What is a key consideration when prescribing triptans for children?
• Which statement best describes riboflavin therapy in migraine prevention?
• The new guidance for migraine prevention encouraged which therapies as first-line?
• In elderly patients, which medication class should be avoided due to anticholinergic burden?
• When is dihydroergotamine (DHE) used in acute migraine management?
• Medication-overuse headache is most commonly associated with overuse of which type of medications?
• Which of the following is a common adverse drug reaction associated with NSAIDs?
• Which anti-CGRP monoclonal antibody is marketed as Aimovig?
• Which factor is essential when dosing triptans in children?
• Which therapy is primarily preventive, requiring injections at regular intervals?
• What is the role and typical dose of magnesium in migraine prevention?
• Sumatriptan in pregnancy is considered:
• What are the common adverse effects of propranolol when used for migraine prevention?
• In migraine management, when are ergotamines considered?
• Which statement best describes the state of approvals for pediatric triptans as per source?
• Which statement about episodic cluster headaches is true?
• Which statement about weight-based dosing for pediatric triptans is true?
• What is one reason that pediatric dosing differs from adult dosing?
• Neuroimaging is necessary in migraine patients in which circumstances?
• Which feature is characteristic of tension-type headache symptoms?
• Dihydroergotamine (DHE) is commonly used for status migrainosus via which routes?
• What is the main advantage of CGRP monoclonal antibodies for long-term migraine control?
• Which type of migraine is listed as a contraindication to triptan therapy?
• What is the primary reason for limiting triptan use to no more than 10 days per month?
• Which statement about acetaminophen use in pregnancy is correct?
• Which CGRP monoclonal antibody is ligand-targeting and used for migraine prevention?
• A common strategy to manage ergotamine-associated nausea is:
• Which preventive therapy for tension-type headache is a tricyclic antidepressant?
• Which non-drug option provides rapid relief for acute cluster headache?
• What is the most severe of the primary headache disorders?
• Which option is NOT used for migraine prophylaxis?
• Which of the following is an adverse drug reaction associated with fremanezumab (Ajovy)?
• Name a commonly used beta-blocker for migraine prevention and one key side effect to monitor.
• Which of the following describes a sensory feature that can occur with tension-type headaches?
• Which of the following is an adverse reaction associated with galcanezumab?
• When combining triptans with SSRIs/SNRIs or MAO inhibitors, what syndrome is of concern?
• Which statement best explains why triptans are commonly used after OTC products for acute migraine?
• What is a major safety concern with acetaminophen use?
• What is a commonly observed consideration when initiating triptans for migraine?
• Which is a stated goal of acute migraine treatment?
• According to ICHD-3 criteria, what constitutes migraine with aura?
• In tension-type headaches, where is the pain most commonly located?
• Which of the following describes acute migraine treatment options?
• What is the mechanism of action of onabotulinumtoxin A in migraine prophylaxis?
• Migraine with aura requires at least how many attacks?
• Which medications are used as adjuncts for nausea in acute migraine treatment?
• Which statement about tension-type headache symptoms is true?
• Which of the following is an adverse effect of ergotamines?
• For acute migraine that is refractory to initial treatment in the emergency department, which therapy is used?
• Which statement about DHE administration is correct?
• Which is NOT listed as a preventive therapy for tension-type headache?
• What is a newer prescription combination product for migraine that includes a NSAID and a triptan?
• Which medication is used for moderate-severe tension-type headache in office or emergency settings?
• Which CGRP ligand-targeting monoclonal antibody is used for migraine prevention?
• What are the adverse drug reactions of atogepant (Qulipta)?
• What is the clinical presentation of cluster headache?
• Over what time frame do typical migraine attacks unfold?
• Which option correctly identifies a CGRP-targeted prophylaxis therapy?
• What distinguishes gepants from triptans in terms of vascular effects?
• Which statement best describes differences between CGRP monoclonal antibodies and onabotulinumtoxinA in prevention?
• What is first-line therapy for mild to moderate acute episodic migraine?
• Which of the following best describes dosing differences for pediatric migraine medications?
• What is the typical maximum daily dose of sumatriptan?
• What is indomethacin-responsive headache and which diagnosis is classic?
• Which scenario most clearly requires urgent secondary evaluation and imaging?
• What is the hallmark of cluster headaches?
• Which statement about acute migraine treatment includes ergotamines?
• Which adverse effects are associated with valproate used for migraine prevention?
• What is the mechanism of action of triptans in migraine treatment?
• Which statement about diagnostic testing for migraine is true?
• Which of the following statements is NOT a diagnostic criterion for migraine with aura?
• In pediatric migraine treatment, what is true about approved therapies and dosing?
• Before initiating verapamil for cluster headache prophylaxis, which assessment is required?
• Which of the following is a potential adverse effect of NSAIDs?
• Which therapy is primarily preventive, requiring injections at regular intervals?
• When evaluating a patient with suspected migraine, which examination should be performed?
• Which agent is a CGRP receptor antagonist approved for acute migraine treatment?
• Which medication is a cluster headache preventive therapy besides verapamil?
• Which neuromodulation devices are approved for patients aged 12 and older?
• For cluster headache, an attack lasts how long?
• In migraine abortive therapy, which category is commonly used and available OTC?
• Which CGRP mAb is given by IV infusion every 12 weeks?
• Considering pediatric migraine treatment, the statement 'some triptans have pediatric approvals with weight-based dosing' implies which of the following?
• Which agent is NOT used for cluster headache prophylaxis?
• For which patient population is topiramate particularly attractive due to weight loss and migraine reduction?
• Which of the following describes adverse drug reactions associated with beta blockers used for migraine prophylaxis?
• Which statement best captures the reason for pediatric-specific safety data?
• Name two CGRP pathway blocking agents approved for migraine prevention and their general mode of administration.
• What pattern of pain distribution is described for tension-type headaches?
• The CGRP receptor antagonists include erenumab, ubrogepant, rimegepant, and atogepant as receptor targets. This category is best described as:
• Two antidepressants used for migraine prevention and one key adverse effect to monitor.
• Which class of medications includes propranolol, metoprolol, and nadolol used for migraine prevention?
• Which statement is part of the diagnostic criteria for tension-type headaches?
• What is the MOA of calcitonin gene-related peptide antagonists?
• Which route is typical for gepants when used for acute treatment?
• Which medication is used for prevention of tension-type headaches?
• What are the common injection-site reactions for CGRP monoclonal antibodies?
• Which agent is a CGRP antagonist used for cluster headache prophylaxis?
• What is a primary goal of acute migraine treatment?
• Which neurostimulation approach has been explored for cluster headache prophylaxis?
• Which therapy is listed as abortive for acute cluster headaches?
• Which vital signs are noted as potentially abnormal in migraine patients?
• Which agents are gepants used for migraine management?
• Which of the following are oral CGRP antagonists used for migraine prevention?
• Which statement best describes the benefit of acetaminophen in migraine management?
• What is the role and typical dose of riboflavin in migraine prevention?
• Palpation of which muscles can reveal tender spots in tension headaches?
• Neuromodulation devices for migraine operate by which mechanism?
• Which of the following findings could be observed on palpation/auscultation of the head and neck in migraine patients?
• Which statement about migraine treatment in pregnancy is accurate?
• Which medication class is not used for migraine treatment?
• What is the mechanism of action of NSAIDs and acetaminophen in migraine treatment?
• Which patient-specific characteristics should migraine therapy be tailored to?
• Which anti-CGRP monoclonal antibody is marketed as Ajovy?
• What is the primary pharmacologic approach for preventing chronic migraine?
• Which CGRP monoclonal antibody is a receptor-targeted therapy?
• Medication-overuse headache (MOH) diagnostic threshold typically involves headache on how many days per month due to overuse of acute medications?
• Which triptan is cited as having pediatric approval with weight-based dosing?
• Which medications are commonly considered second-line after NSAIDs for acute episodic migraine?
• What is a typical maximum daily dose for sumatriptan in acute migraine therapy?
• Which statement is a criterion for migraine prophylaxis candidacy?
• Which of the following is a first-line preventive therapy for cluster headache?
• What safety concern arises when combining triptans with SSRIs/SNRIs or MAO inhibitors?
• List a major contraindication to triptan use.
• Which combination of red-flag features most strongly suggests a secondary headache requiring urgent evaluation?
• Which of the following is a potential example of weight-based dosing concept for pediatric triptans?
• Which ergotamine preparation is uncommonly prescribed?
• In acute migraine management, triptans are commonly used in combination with which of the following to enhance efficacy?
• Which statement best describes the cardiovascular safety profile of CGRP antagonists?
• What is a typical first-line acute treatment for a healthy adult with moderate migraine without cardiovascular risk?
• Which of the following describes the adverse drug reactions of eptinezumab (Vyepti)?
• Basilar migraine has a relative contraindication to the use of which class of drugs?
• In acute migraine therapy, NSAIDs provide analgesia and anti-inflammatory effects and are often used with triptans; chronic overuse should be avoided due to GI/renal risk.
• What is lasmiditan's mechanism and a major driving safety caveat?
• Which therapy is categorized as 'other' for migraine prevention?
• Which statement best describes the goals of migraine prophylaxis?
• Which of the following is an anti-seizure medication used for migraine prophylaxis?
• Which CGRP monoclonal antibody is used for migraine prevention or cluster headache prophylaxis as listed?
• Which of the following is a beta blocker used for migraine prophylaxis?
• Are triptans contraindicated with other serotonergic agents due to serotonin syndrome?
• Neuroimaging studies indicate what in cluster headaches?
• Which adverse effects are associated with divalproex?
• Which statement about imaging in cluster headache is true?
• For chronic migraine, which dosing option reflects onabotulinumtoxin A administration?
• Which sequence describes the pathophysiology of migraine?
• Which adverse effect is associated with topiramate?
• Which condition is a contraindication to triptan therapy?
• Which therapy is often useful for menstrual-related migraine?
• OnabotulinumtoxinA is administered by which route for chronic migraine?
• How do CGRP monoclonal antibodies differ from gepants in clinical use?
• Which of the following is NOT a component of the POUND mnemonic?
• Which statement correctly distinguishes gepants from monoclonal antibodies in CGRP-targeted therapy?
• Which neuromodulation device is also approved for cluster headache?
• Ergot alkaloids in acute migraine therapy produce what effect and what are key contraindications?
• Triptans may cause which cardiac effect at therapeutic doses?
• Which nonpharmacologic therapies are recommended for migraine management?
• What is one proposed mechanism by which caffeine enhances migraine relief when combined with analgesics?
• How long do migraine without aura attacks typically last?
• Which precaution is correct regarding migraine management in pregnancy?
• Which statement accurately describes menstrual-related migraine management?
• Which CGRP monoclonal antibody is listed for cluster headache prevention?
• Which statement best characterizes the tolerability of CGRP monoclonal antibodies?
• For tension-type headache abortive therapy, which option is NOT listed?
• What are the four phases of migraine progression?
• What neuro exam findings could be abnormal in migraine patients?
• Which agent functions as a gepant?
• Which product is an ergotamine combination used for migraine?
• Dihydroergotamine (DHE) is typically administered by which routes for acute migraine management?
• Which medication is associated with nasopharyngitis and hypersensitivity as adverse effects?
• What is the trigger for tension-type headache?
• Which of the following statements is characteristic of cluster headaches?
• Which of the following is an adverse effect particularly noted with CGRP antagonists in nasal spray form?
• What is the maximum number of triptan tablets allowed in 24 hours?
• Which anti-CGRP monoclonal antibody is marketed as Emgality?
• What is the recommended approach to migraine medications during pregnancy?
• Which combination is used in Excedrin Migraine?
• Which of the following is an angiotensin II receptor blocker (ARB) used for migraine prophylaxis?