Which condition is a contraindication to triptan therapy?

Which condition is a contraindication to triptan therapy?

• A. Uncontrolled hypertension
• B. Migraine with aura
• C. Asthma
• D. Controlled hypertension

Answer: (A)

Triptans work by activating 5-HT1B/1D receptors to cause cranial vasoconstriction and to inhibit neuropeptide release, helping alleviate migraine pain. In someone with uncontrolled hypertension, this additional vasoconstriction can raise blood pressure further and increase the risk of cardiovascular events such as stroke or myocardial ischemia. That’s why uncontrolled hypertension is a contraindication to triptan therapy. Migraine with aura alone is not a blanket contraindication; the decision depends on overall cardiovascular risk, but aura by itself does not automatically preclude use. Asthma is not a contraindication for most patients. Controlled hypertension is compatible with triptan use, often with standard precautions.

Triptans work by activating 5-HT1B/1D receptors to cause cranial vasoconstriction and to inhibit neuropeptide release, helping alleviate migraine pain. In someone with uncontrolled hypertension, this additional vasoconstriction can raise blood pressure further and increase the risk of cardiovascular events such as stroke or myocardial ischemia. That’s why uncontrolled hypertension is a contraindication to triptan therapy.

Migraine with aura alone is not a blanket contraindication; the decision depends on overall cardiovascular risk, but aura by itself does not automatically preclude use. Asthma is not a contraindication for most patients. Controlled hypertension is compatible with triptan use, often with standard precautions.