Which statement about adverse effects of CGRP antagonists is NOT true?

Which statement about adverse effects of CGRP antagonists is NOT true?

• A. They are generally well tolerated
• B. They can cause taste changes
• C. They can cause new-onset Raynaud's phenomenon
• D. They cause significant hematologic toxicity

Answer: (D)

CGRP antagonists have a generally favorable safety profile with adverse effects that are usually mild and non-hematologic. Taste changes (dysgeusia) have been reported with this class, and there are notes of vasospastic phenomena like new-onset Raynaud’s in some patients due to reduced CGRP-mediated vasodilation. In contrast, significant hematologic toxicity is not a characteristic feature of CGRP antagonists, so the statement claiming they cause major hematologic toxicity is not true.

CGRP antagonists have a generally favorable safety profile with adverse effects that are usually mild and non-hematologic. Taste changes (dysgeusia) have been reported with this class, and there are notes of vasospastic phenomena like new-onset Raynaud’s in some patients due to reduced CGRP-mediated vasodilation. In contrast, significant hematologic toxicity is not a characteristic feature of CGRP antagonists, so the statement claiming they cause major hematologic toxicity is not true.