Which statement about CGRP monoclonal antibodies is most accurate?

Which statement about CGRP monoclonal antibodies is most accurate?

• A. They are used only for acute treatment.
• B. They are rarely tolerated.
• C. They require daily dosing and have many drug interactions.
• D. They provide long-acting prevention with substantial reduction in monthly migraine days and are generally well tolerated.

Answer: (D)

CGRP monoclonal antibodies are preventive migraine therapies with a long-acting effect, given by monthly or quarterly dosing and with a favorable tolerability profile. They’re not used for acute treatment, and they aren’t taken daily; they’re not associated with meaningful drug–drug interactions because they’re degraded by proteolysis rather than hepatic enzymes. In trials, these agents produce a meaningful reduction in monthly migraine days for many patients and are generally well tolerated, with injection-site reactions being the most common and systemic adverse effects relatively infrequent. This combination of durable preventive benefit and good tolerability makes the statement describing long-acting prevention with a substantial reduction in monthly migraine days and good tolerability the most accurate.

CGRP monoclonal antibodies are preventive migraine therapies with a long-acting effect, given by monthly or quarterly dosing and with a favorable tolerability profile. They’re not used for acute treatment, and they aren’t taken daily; they’re not associated with meaningful drug–drug interactions because they’re degraded by proteolysis rather than hepatic enzymes. In trials, these agents produce a meaningful reduction in monthly migraine days for many patients and are generally well tolerated, with injection-site reactions being the most common and systemic adverse effects relatively infrequent. This combination of durable preventive benefit and good tolerability makes the statement describing long-acting prevention with a substantial reduction in monthly migraine days and good tolerability the most accurate.